Epiregulin is released from intervertebral disks and induces spontaneous activity in pain pathways
نویسندگان
چکیده
منابع مشابه
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Epoxyeicosatrienoic acids (EETs) are cytochrome P450-epoxygenase-derived metabolites of arachidonic acid that act as endogenous signaling molecules in multiple biological systems. Here we have investigated the specific contribution of 5,6-EET to transient receptor potential (TRP) channel activation in nociceptor neurons and its consequence for nociceptive processing. We found that, during capsa...
متن کاملEpiregulin and EGFR interactions are involved in pain processing.
The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG), in pain processing. We show that inhibition of EGFR with clinically available compounds strongly ...
متن کاملTerminology for herniation of intervertebral disks.
of that relationship are understood, and that joint disorders other than internal derangements occasionally occur. The difficulty I have is that the physician-dentist community at large is not united in its approach to TMJ problems. This stems in part from the diversity of specialists and generalists who involve themselves in this area of medicine; the TMJ has been claimed by everyone but not r...
متن کاملImagistic and histopathologic concordances in degenerative lesions of intervertebral disks.
Lumbar disk lesions in 47 cases were initially diagnosed using MRI investigation, then, after surgery, biological and histopathological aspects of intervertebral disks were revealed. Pieces from intervertebral disks were used for electron microscopy studies in order to determine collagen in the components of the intervertebral disk. The aim of the present study was to highlight the corresponden...
متن کاملEconazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways
Econazole nitrate (EN), a synthetic compound, is now in use as a routine antifungal drug. EN was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. In this research, the apoptosis-inducing effect of EN on MCF-7 cells was investigated. The results showed that EN inhibited the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PAIN Reports
سال: 2019
ISSN: 2471-2531
DOI: 10.1097/pr9.0000000000000718